First isolated from a lupine seedling and characterized in 1886,
L-arginine is one of the twenty typical a-amino acids used as
building blocks for protein. As such, it is present in a wide
variety of foods of both plant and animal origin with particularly
high levels found in eggs, almonds, spinach, and lobster.
L-arginine is considered to be conditionally essential, meaning
that for most adults adequate levels of arginine can be obtained
from the diet or through biosynthesis/recycling. However during
growth, and at other times when positive nitrogen balance is
required, such as during healing, diet, and biosynthesis, may not
meet arginine needs since the rate of biosynthesis does not
compensate for depletion or inadequate supply.
In addition, research evaluating the effects of arginine on the
structure and function of the body often utilizes serving sizes in
the multi-gram range, which may be difficult to achieve with food
- 1000 mg per tablet
- Pharmaceutical grade L-Arginine
- Easy-Solv tablets
Aside from incorporation into proteins, one of the primary
functions of L-arginine is as a precursor to nitric oxide (NO).
Nitric oxide synthase (NOS) generates NO from L-arginine, producing
citrulline as a byproduct. The recycling of citrulline back to
L-arginine is possible via the citrulline-arginine pathway, but it
is an energy intensive and inefficient process that the body does
not rely on for its arginine needs.
NO is a critical mediator of vascular regulation, immune activity,
and endocrine function.When it comes to the cardiovascular system,
this gaseous messenger has a number of effects. It is necessary for
endothelium-dependent vasodilation, allowing blood vessels to relax
and widen. As such, the role of NO in maintaining healthy blood
pressure has been studied in depth. In addition, NO also modulates
platelet aggregation and the inflammatory response.
Creatine Connection, Immune Function, And Repair
Creatine helps to supply energy to all cells in the body, primarily
muscle. However, it is not an essential nutrient because it can be
produced in the body from L-arginine, glycine, and L-methionine.
The first step of creatine biosynthesis is carried out by
arginine:glycine amidinotransferase. Thus, the use of arginine as a
precursor to creatine is part of the allure to athletes, but
arginine administration has also been observed to stimulate the
release of growth hormone.
*The mechanism by which this could occur is unknown, but may be
interwoven with the effect of arginine on creatine regulation.*
L-arginine has been found to affect levels of a number of immune
modulators and cell adhesion molecules.* This coupled with effects
on inflammatory balance and tissue generation make it
understandable how arginine can be an important supporter of normal
healing.* It appears that tissue injury, particularly of the skin,
causes an increase in arginine oxidation and can deplete reserves.
*These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat,
cure, or prevent any disease.